默克药用低内毒素系列产品的生产工艺、生产环境、包装系统均严格符合高风险制剂的生产和研发要求。该系列产品以极低的内毒素/微生物控制水平以及全球领先的杂质控制技术大大降低了除菌工艺的风险和确保了制剂的长期稳定性。EMPROVE®文件系统,参考 ICH Q9 和 EU 2015/C95/02 提供风险评估支持,为国际化产品提供法规助力。 

货号:111597

品名:Parteck® SI 400 LEX Sorbitolsuitable for use asexcipient EMPROVE® Essential Ph Eur,BP,NF,JP

中文名:Parteck® 山梨醇400(低内毒素)

内毒素:1 I.U./g

TAMC(总菌):200 CFU/g

 

TYMC(霉菌/酵母):100 CFU/g

山梨醇400(低内毒素)  Parteck® Sorbitol 111597
规格
Assay (HPLC, calc.on anhydrous substance) 97.0 - 100.5 %
Identity passes test
pH-value (10 %; water) 3.5 - 7.0
Appearance of solution (25 %; water) passes test
Spec. rotation (α20/D, 10 %, borate complex, calc. on anhydrous substance) +4.0 - +7.0 °
Conductivity (25°C) (20 %; water) ≤ 20
Chloride (Cl) ≤ 0.002 %
Sulphate (SO₄) ≤ 0.006 %
Heavy metals (as Pb) ≤ 0.0005 %
As (Arsenic) ≤ 0.00013 %
Ni (Nickel) (#) ≤ 0.0001 %
Pb (Lead) ≤ 0.00005 %
Related substances (HPLC, EP) (Major impurity (Mannitol)) ≤ 2.0 %
Related substances (HPLC, EP) (Sum of all impurities) ≤ 3.0 %
Reducing sugars after hydrolysis/total sugar (as glucose) ≤ 0.8
Reducing sugars (as glucose) ≤ 0.11 %
Sulfated ash ≤ 0.02 %
Loss on drying ≤ 2.0 %
Water ≤ 1.5 %
Residual solvents (ICH Q3C) excluded by manufacturing process
Microbiological test passes test
Colony count (aerobic bacteria (TAMC)) ≤ 2*10²
Colony count (Yeasts and moulds (TYMC)) ≤ 10²
Salmonella spp. in 10g Substance not detectable
E.coli in 1g substance not detectable
Pseudomonas aeruginosa in 1g substance not detectable
Staphylococcus aureus in 1g substance not detectable
Candida albicans In 1g substance not detectable
Endotoxins ≤ 1
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
corresponds to Ph. Eur., BP, NF, JP